Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

Abstract Background Epigenetic alteration is an important indicator of crosstalk between cancer cells and surrounding microenvironment components including mesenchymal stem cells (MSC). Human menstrual blood-derived stem cells (MenSCs) are novel source of MSCs which exert suppressive effects on canc...

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Bibliographic Details
Main Authors: Yichen Wu, Xin Chen, Yongjia Zhao, Yanling Wang, Yifei Li, Charlie Xiang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
HCC
Epigenetics
5-Hydroxymethylcytosine
Enhancer
Online Access:http://link.springer.com/article/10.1186/s13287-019-1243-8

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