Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness

Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness

Molecular pathological pathways leading to multi-organ failure in critical illness are progressively being unravelled. However, attempts to modulate these pathways have not yet improved the clinical outcome. Therefore, new targetable mechanisms should be investigated. We hypothesize that increased d...

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Bibliographic Details
Main Authors: Bas C. T. van Bussel, Marcel C. G. van de Poll, Casper G. Schalkwijk, Dennis C. J. J. Bergmans
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:International Journal of Molecular Sciences
Subjects:
dicarbonyl stress
glyoxalase
methylglyoxal
critical care
multi-organ failure
persistent critical illness
Online Access:http://www.mdpi.com/1422-0067/18/2/346

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