Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells.

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells.

Timely characterization of a cancer's evolution is required to predict treatment efficacy and to detect resistance early. High content analysis of single Circulating Tumor Cells (CTCs) enables sequential characterization of genotypic, morphometric and protein expression alterations in real time...

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Bibliographic Details
Main Authors: Angel E Dago, Asya Stepansky, Anders Carlsson, Madelyn Luttgen, Jude Kendall, Timour Baslan, Anand Kolatkar, Michael Wigler, Kelly Bethel, Mitchell E Gross, James Hicks, Peter Kuhn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4118839?pdf=render

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