Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.

Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.

Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates. Increased levels of homocysteine in blood are associated with cardiovascular disease. Given their role in human health and nutr...

Full description

Bibliographic Details
Main Authors:	Radhika S Ganu, Yasuko Ishida, Markos Koutmos, Sergios-Orestis Kolokotronis, Alfred L Roca, Timothy A Garrow, Lawrence B Schook
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4516251?pdf=render

Similar Items

Evaluation of common polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and betaine-homocysteine methyltransferase (BHMT)
by: Weisberg, Ilan S.
Published: (1999)

Exploring effects of betaine-homocysteine methyltransferase (BHMT) gene polymorphisms on fatty acid traits and cholesterol in sheep
by: J. P. Munyaneza, et al.
Published: (2019-09-01)

The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
by: Sarah Sternbach, et al.
Published: (2021-01-01)

Structural and Signaling Elements Important for the Efficient Degradation of BHMT through Macroautophagy
by: Mercer, Carol A.
Published: (2007)

Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy
by: Jose M. Colomina, et al.
Published: (2016-10-01)

Association between BHMT gene rs3733890 polymorphism and cancer risk: evidence from a meta-analysis
by: Xu Y, et al.
Published: (2016-08-01)

Homocysteine homeostasis and betaine-homocysteine S-methyltransferase expression in the brain of hibernating bats.
by: Yijian Zhang, et al.
Published: (2013-01-01)

Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase.
by: Francisco Garrido, et al.
Published: (2018-01-01)

The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
by: Rima Obeid
Published: (2013-09-01)

Betaine Homocysteine Methyltransferase, Disease and Diet: The Use of Proton Nuclear Magnetic Resonance on Biological Methylamines
by: Lee, Martin Bryce
Published: (2008)

Effects of zinc supplementation and betaine substitution to methionine on hepatic betaine - homocysteine methyltransferase and lipogenic genes expression in laying hens under heat stress
by: Mahmood Naziri, et al.
Published: (2017-06-01)

Glycine Betaine and Proline Betaine Specific Methyltransferases of the MttB Superfamily
by: Picking, Jonathan William
Published: (2019)

Studium fyziologických funkcí betain homocystein S-methyltransferasy a betain homosystein S-methyltransferasy 2
by: Mládková, Jana
Published: (2013)

Efeito da concentração de metionina na dieta durante o período pré e pósnatal sobre o estresse oxidativo, a instabilidade genômica e expressão de RNAm de Mat1a, Bhmt e Cbs em camundongos
by: Tarsila Daysy Ursula Hermogenes Gomes
Published: (2013)

Efeito da concentração de metionina na dieta durante o período pré e pósnatal sobre o estresse oxidativo, a instabilidade genômica e expressão de RNAm de Mat1a, Bhmt e Cbs em camundongos
by: Gomes, Tarsila Daysy Ursula Hermogenes
Published: (2013)

Protective effects of betaine-homocysteine methyl transferase on oxidative damaged human lens epithelial cells induced by high homocysteine
by: Hai-Yan Zhou, et al.
Published: (2019-10-01)

Systematic Comparisons of Orthologous Selenocysteine Methyltransferase and Homocysteine Methyltransferase Genes from Seven Monocots Species
by: De-yong ZHAO, et al.
Published: (2015-06-01)

Systematic Comparisons of Orthologous Selenocysteine Methyltransferase and Homocysteine Methyltransferase Genes from Seven Monocots Species
by: De-yong ZHAO, et al.
Published: (2015-06-01)

Reconciling apparent conflicts between mitochondrial and nuclear phylogenies in African elephants.
by: Yasuko Ishida, et al.
Published: (2011-01-01)

The real maccoyii: identifying tuna sushi with DNA barcodes--contrasting characteristic attributes and genetic distances.
by: Jacob H Lowenstein, et al.
Published: (2009-11-01)

Genetic variation at hair length candidate genes in elephants and the extinct woolly mammoth
by: Tisdale Michele, et al.
Published: (2009-09-01)

S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase.
by: Hui Chen, et al.
Published: (2013-01-01)

Purification of S-methyl-L-methionine : homocysteine methyltransferase in Triticum aestivum (Gramineae)
by: Bryan, James E.
Published: (2011)

The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments.
by: Michael Lever, et al.
Published: (2012-01-01)

Contribution of 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase Genotypes to Colorectal Cancer in Taiwan
by: Bau, D.-A.-T, et al.
Published: (2022)

The biosynthesis of glycine betaine in halophilic methanogenic archaea Methanohalophilus portucalensis FDF1 and the purification of glycine N-methyltransferase
by: Chuang, Ming-Jen, et al.
Published: (1997)

Structural studies of the sarcosine dimethylglycine methyltransferase from Methanohalophilus portucalensis FDF1T, an enzyme involved in betaine biosynthesis
by: Te-Sheng Lin, et al.
Published: (2015)

Homocysteine Induces Collagen I Expression by Downregulating Histone Methyltransferase G9a.
by: Wenjing Lei, et al.
Published: (2015-01-01)

5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer
by: A.L.S. Galbiatti, et al.
Published: (2010-05-01)

Detection of mitochondrial insertions in the nucleus (NuMts) of Pleistocene and modern muskoxen
by: MacPhee Ross DE, et al.
Published: (2007-04-01)

Purification and Characterization of Osmolyte Betaine Synthesizing Enzyme-Glycine N-methyltransferase from Methanohalophilus portucalensis strain FDF1
by: Yen-Chi Wu, et al.
Published: (2001)

Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases
by: Purta Elzbieta, et al.
Published: (2007-03-01)

Bats, Primates, and the Evolutionary Origins and Diversification of Mammalian Gammaherpesviruses
by: Marina Escalera-Zamudio, et al.
Published: (2016-11-01)

Purification and Characterization of Osmolyte Betaine Synthesizing Enzyme-Sarcosine Dimethylglycine N-Methyltransferase from Methanohalophilus portucalensis strain FDF1
by: Shih-Ya Chen, et al.
Published: (2006)

Purification and characterization of osmolyte glycine betaine synthesizing enzyme glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis FDF1T
by: Yu-Chen Deng, et al.
Published: (2014)

The betaine/GABA transporter and betaine: roles in brain, kidney and liver
by: Stephen A Kempson, et al.
Published: (2014-04-01)

Betaine Transport in Kidney and Liver: Use of Betaine in Liver Injury
by: Stephen A. Kempson, et al.
Published: (2013-12-01)

On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.
by: Tomasz P Jurkowski, et al.
Published: (2011-01-01)

S-Adenosyl- L-Methionine And S-Adenosyl- L-Homocysteine: A Nuclear Magnetic Resonance Study And Purification Of S-Adenosyl- L-Methionine: L-Homocysteine S-Methyltransferase From Saccharomyces Cerevisiae
by: Stolowitz, Mark Lewis
Published: (1981)

Purification and Activity assay of Osmolyte Betaine Synthesizing Enzyme-Sarcosine Dimethylglycine N-methyltransferase from Methanohalophilus portucalensis strain FDF1
by: Yu-Chien Lee, et al.
Published: (2004)