Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

DYRK1A, dual-specificity tyrosine-regulated kinase 1A, maps to human chromosome 21 within the Down syndrome (DS) critical region. Dyrk1 phosphorylates the human microtubule-associated protein tau at Thr212 in vitro, a residue that is phosphorylated in fetal tau and hyper-phosphorylated in Alzheimer...

Full description

Bibliographic Details
Main Authors: Isidro Ferrer, Marta Barrachina, Berta Puig, M. Martínez de Lagrán, Eulalia Martí, Jesús Avila, Mara Dierssen
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Dyrk1
Alzheimer disease
Down syndrome
Pick disease
tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000835

Similar Items

Similar Items