DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.

Methylation of tumor suppressor gene promoter leads to transcription inactivation and is involved in tumorigenesis. Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological g...

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Main Authors: Lihe Dai, Chong Ma, Zhensheng Zhang, Shuxiong Zeng, Anwei Liu, Shijie Tang, Qian Ren, Yinghao Sun, Chuanliang Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5132202?pdf=render
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spelling doaj-776c9596e93f495f8964b9602864fee82020-11-25T01:49:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016722810.1371/journal.pone.0167228DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.Lihe DaiChong MaZhensheng ZhangShuxiong ZengAnwei LiuShijie TangQian RenYinghao SunChuanliang XuMethylation of tumor suppressor gene promoter leads to transcription inactivation and is involved in tumorigenesis. Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological grade. Due to inconsistent results of these studies, we performed this meta-analysis to ascertain the association.Studies were retrieved from the PubMed, Embase, Web of Science and the Cochrane Library databases. Study selection and data extraction were executed by two reviewers independently. Meta-analysis was performed using Stata 13.0 and Review Manager 5.3 software.A total of 21 articles involving 15 case control and 8 case series studies were included in this meta-analysis. DAPK promoter methylation was associated with bladder cancer risk (OR: 5.81; 95%CI = 3.83-8.82, P<0.00001). The frequency of DAPK promoter methylation was equal in bladder cancer tissue and paired adjacent normal tissue (OR: 0.87; 95%CI = 0.31-2.48, P = 0.794). Furthermore, DAPK promoter methylation was associated with higher histological grade (OR: 1.52; 95%CI = 1.10-2.09, P = 0.011) but not associated with tumor stage (OR: 1.12; 95%CI = 0.67-1.87, P = 0.668).The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.http://europepmc.org/articles/PMC5132202?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Lihe Dai
Chong Ma
Zhensheng Zhang
Shuxiong Zeng
Anwei Liu
Shijie Tang
Qian Ren
Yinghao Sun
Chuanliang Xu
spellingShingle Lihe Dai
Chong Ma
Zhensheng Zhang
Shuxiong Zeng
Anwei Liu
Shijie Tang
Qian Ren
Yinghao Sun
Chuanliang Xu
DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.
PLoS ONE
author_facet Lihe Dai
Chong Ma
Zhensheng Zhang
Shuxiong Zeng
Anwei Liu
Shijie Tang
Qian Ren
Yinghao Sun
Chuanliang Xu
author_sort Lihe Dai
title DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.
title_short DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.
title_full DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.
title_fullStr DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.
title_full_unstemmed DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.
title_sort dapk promoter methylation and bladder cancer risk: a systematic review and meta-analysis.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description Methylation of tumor suppressor gene promoter leads to transcription inactivation and is involved in tumorigenesis. Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological grade. Due to inconsistent results of these studies, we performed this meta-analysis to ascertain the association.Studies were retrieved from the PubMed, Embase, Web of Science and the Cochrane Library databases. Study selection and data extraction were executed by two reviewers independently. Meta-analysis was performed using Stata 13.0 and Review Manager 5.3 software.A total of 21 articles involving 15 case control and 8 case series studies were included in this meta-analysis. DAPK promoter methylation was associated with bladder cancer risk (OR: 5.81; 95%CI = 3.83-8.82, P<0.00001). The frequency of DAPK promoter methylation was equal in bladder cancer tissue and paired adjacent normal tissue (OR: 0.87; 95%CI = 0.31-2.48, P = 0.794). Furthermore, DAPK promoter methylation was associated with higher histological grade (OR: 1.52; 95%CI = 1.10-2.09, P = 0.011) but not associated with tumor stage (OR: 1.12; 95%CI = 0.67-1.87, P = 0.668).The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.
url http://europepmc.org/articles/PMC5132202?pdf=render
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