The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation

The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation

<p>Abstract</p> <p>Background</p> <p>Surfactant protein C (SP-C) is important for the function of pulmonary surfactant. Heterozygous mutations in <it>SFTPC</it>, the gene encoding SP-C, cause sporadic and familial interstitial lung disease (ILD) in children...

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Main Authors: Zarbock Ralf, Woischnik Markus, Sparr Christiane, Thurm Tobias, Kern Sunčana, Kaltenborn Eva, Hector Andreas, Hartl Dominik, Liebisch Gerhard, Schmitz Gerd, Griese Matthias
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Pulmonary Medicine
Online Access:http://www.biomedcentral.com/1471-2466/12/15

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