White matter hyperintensities affect transcranial electrical stimulation in the aging brain

• Main Authors: Aprinda Indahlastari, Alejandro Albizu, Emanuel M. Boutzoukas, Andrew O’Shea, Adam J. Woods
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Brain Stimulation
• Subjects: tES; Aging; White matter hyperintensity; Finite element model
• Online Access: http://www.sciencedirect.com/science/article/pii/S1935861X20302965

Background: White matter hyperintensities (WMH) are estimated to occur in greater than 63% of older adults over the age of 60 years. WMH identified in the T2-weighted FLAIR images can be combined with T1-weighted images to enhance individualized current flow models of older adults by accounting for the presence of WMH and its effects on delivered tES current in the aging brain. Methods: Individualized head models were derived from T1-weighted images of 130 healthy older adults (mean = 71 years). Lesions segmented from FLAIR acquisition were added to individualized models. Current densities were computed in the brain and compared between models with and without lesions. Main results: Integrating WMH into the models resulted in an overall decrease (up to 7%) in median current densities in the brain outside lesion regions. Changes in current density and total lesion volume was positively correlated (R2 = 0.31, p < 0.0001). Conclusions: Incorporating WMH into individualized models may increase the accuracy of predicted tES current flow in the aging brain.