Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway

Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway

Vascular calcification is strongly associated with atherosclerotic plaque burden and plaque instability. The activation of extracellular signal-regulated kinase 1/2 (ERK1/2) increases runt related transcription factor 2 (RUNX2) expression to promote vascular calcification. Procyanidin B2 (PB2), a po...

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Bibliographic Details
Main Authors: Yingquan Liang, Guilan Chen, Feng Zhang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan, Maoyun Yu, Shuang Zhang, Jihong Han
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
vascular calcification
procyanidin B2
ERK1/2
RUNX2
apoE<sup>−/−</sup> mice
Online Access:https://www.mdpi.com/2076-3921/10/6/916

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