Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique...

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Bibliographic Details
Main Authors: Byungchul Kim, Yen-Chih Wang, Charles W Hespen, Juliel Espinosa, Jeanne Salje, Kavita J Rangan, Deena A Oren, Jin Young Kang, Virginia A Pedicord, Howard C Hang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
Enterococcus
peptidoglycan
microbiota
commensal bacteria
intestinal barrier
NOD2
Online Access:https://elifesciences.org/articles/45343

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