ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10967-7 |
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doaj-7757796c1cc14b99b37e09335d62edfc2021-05-11T11:48:24ZengNature Publishing GroupNature Communications2041-17232019-07-0110111210.1038/s41467-019-10967-7ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin responseAdebowale A. Adeyemo0Norann A. Zaghloul1Guanjie Chen2Ayo P. Doumatey3Carmen C. Leitch4Timothy L. Hostelley5Jessica E. Nesmith6Jie Zhou7Amy R. Bentley8Daniel Shriner9Olufemi Fasanmade10Godfrey Okafor11Benjamin Eghan12Kofi Agyenim-Boateng13Settara Chandrasekharappa14Jokotade Adeleye15William Balogun16Samuel Owusu17Albert Amoah18Joseph Acheampong19Thomas Johnson20Johnnie Oli21Clement Adebamowo22South Africa Zulu Type 2 Diabetes Case-Control Study23Francis Collins24Georgia Dunston25Charles N. Rotimi26Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of MedicineCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of MedicineDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of MedicineDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of MedicineCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthUniversity of LagosUniversity of Nigeria Teaching HospitalUniversity of Science and TechnologyUniversity of Science and TechnologyNational Human Genome Research Institute, National Institutes of HealthCollege of Medicine, University of IbadanCollege of Medicine, University of IbadanUniversity of Ghana Medical SchoolUniversity of Ghana Medical SchoolUniversity of Science and TechnologyUniversity of LagosUniversity of Nigeria Teaching HospitalDepartment of Epidemiology and Public Health; Institute of Human Virology; Greenebaum Comprehensive Cancer Center, School of Medicine, University of MarylandOxford NIHR Biomedical Research CentreNational Institutes of HealthNational Human Genome Center at Howard UniversityCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of HealthType 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.https://doi.org/10.1038/s41467-019-10967-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Adebowale A. Adeyemo Norann A. Zaghloul Guanjie Chen Ayo P. Doumatey Carmen C. Leitch Timothy L. Hostelley Jessica E. Nesmith Jie Zhou Amy R. Bentley Daniel Shriner Olufemi Fasanmade Godfrey Okafor Benjamin Eghan Kofi Agyenim-Boateng Settara Chandrasekharappa Jokotade Adeleye William Balogun Samuel Owusu Albert Amoah Joseph Acheampong Thomas Johnson Johnnie Oli Clement Adebamowo South Africa Zulu Type 2 Diabetes Case-Control Study Francis Collins Georgia Dunston Charles N. Rotimi |
| spellingShingle |
Adebowale A. Adeyemo Norann A. Zaghloul Guanjie Chen Ayo P. Doumatey Carmen C. Leitch Timothy L. Hostelley Jessica E. Nesmith Jie Zhou Amy R. Bentley Daniel Shriner Olufemi Fasanmade Godfrey Okafor Benjamin Eghan Kofi Agyenim-Boateng Settara Chandrasekharappa Jokotade Adeleye William Balogun Samuel Owusu Albert Amoah Joseph Acheampong Thomas Johnson Johnnie Oli Clement Adebamowo South Africa Zulu Type 2 Diabetes Case-Control Study Francis Collins Georgia Dunston Charles N. Rotimi ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response Nature Communications |
| author_facet |
Adebowale A. Adeyemo Norann A. Zaghloul Guanjie Chen Ayo P. Doumatey Carmen C. Leitch Timothy L. Hostelley Jessica E. Nesmith Jie Zhou Amy R. Bentley Daniel Shriner Olufemi Fasanmade Godfrey Okafor Benjamin Eghan Kofi Agyenim-Boateng Settara Chandrasekharappa Jokotade Adeleye William Balogun Samuel Owusu Albert Amoah Joseph Acheampong Thomas Johnson Johnnie Oli Clement Adebamowo South Africa Zulu Type 2 Diabetes Case-Control Study Francis Collins Georgia Dunston Charles N. Rotimi |
| author_sort |
Adebowale A. Adeyemo |
| title |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_short |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_full |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_fullStr |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_full_unstemmed |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_sort |
zranb3 is an african-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population. |
| url |
https://doi.org/10.1038/s41467-019-10967-7 |
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