The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture

The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture

D-galactosamine (GalN) is a highly selective hepatotoxin that causes liver damage similar to human viral hepatitis via depletion of uridine nucleotides, which subsequently diminishes synthesis of RNA and proteins. Model of galactosamine hepatotoxicity is frequently used in animal experiments in vitr...

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Bibliographic Details
Main Authors: Otto Kučera, Halka Lotková, Roman Kanďár, Renata Héžová, Vladimíra Mužáková, Zuzana Červinková
Format: Article
Language:English
Published: Karolinum Press 2006-01-01
Series:Acta Medica
Subjects:
D-galactosamine
Hepatocytes
Lactate Dehydedrogenase
Lipid Peroxidation
Mitochondrial membrane potential
Albumin synthesis
Online Access:https://actamedica.lfhk.cuni.cz/49/1/0059/

Internet

https://actamedica.lfhk.cuni.cz/49/1/0059/

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