Chronic myelomonocytic leukemia as a transformation from polycythemia vera

Chronic myelomonocytic leukemia as a transformation from polycythemia vera

The hallmark of Polycythemia vera (PV) is the presence of JAK2V617F mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1 × 109/L for at least 3 months with myeloid cell dysplasia. Few cases of evolved CMML from...

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Main Authors: Mirela Andrei, Anita Pandey, Boris Avezbakiyev, Jen Chin Wang
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048918300700
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spelling doaj-774eade8ca7540d39df01d17e95bfed82020-11-25T01:28:30ZengElsevierLeukemia Research Reports2213-04892019-01-01111416Chronic myelomonocytic leukemia as a transformation from polycythemia veraMirela Andrei0Anita Pandey1Boris Avezbakiyev2Jen Chin Wang3St Mary's Regional Medical Center, Lewiston, ME, USADivision of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn 11212, NY, USADivision of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn 11212, NY, USADivision of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn 11212, NY, USA; Corresponding author.The hallmark of Polycythemia vera (PV) is the presence of JAK2V617F mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1 × 109/L for at least 3 months with myeloid cell dysplasia. Few cases of evolved CMML from PV have been described. We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2V617F clone. This clone carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14+ CD16−by flow cytometry. Keywords: Chronic myelomonocytic leukemia, Polycythemia vera, Monocytosishttp://www.sciencedirect.com/science/article/pii/S2213048918300700
collection DOAJ
language English
format Article
sources DOAJ
author Mirela Andrei
Anita Pandey
Boris Avezbakiyev
Jen Chin Wang
spellingShingle Mirela Andrei
Anita Pandey
Boris Avezbakiyev
Jen Chin Wang
Chronic myelomonocytic leukemia as a transformation from polycythemia vera
Leukemia Research Reports
author_facet Mirela Andrei
Anita Pandey
Boris Avezbakiyev
Jen Chin Wang
author_sort Mirela Andrei
title Chronic myelomonocytic leukemia as a transformation from polycythemia vera
title_short Chronic myelomonocytic leukemia as a transformation from polycythemia vera
title_full Chronic myelomonocytic leukemia as a transformation from polycythemia vera
title_fullStr Chronic myelomonocytic leukemia as a transformation from polycythemia vera
title_full_unstemmed Chronic myelomonocytic leukemia as a transformation from polycythemia vera
title_sort chronic myelomonocytic leukemia as a transformation from polycythemia vera
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2019-01-01
description The hallmark of Polycythemia vera (PV) is the presence of JAK2V617F mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1 × 109/L for at least 3 months with myeloid cell dysplasia. Few cases of evolved CMML from PV have been described. We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2V617F clone. This clone carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14+ CD16−by flow cytometry. Keywords: Chronic myelomonocytic leukemia, Polycythemia vera, Monocytosis
url http://www.sciencedirect.com/science/article/pii/S2213048918300700
work_keys_str_mv AT mirelaandrei chronicmyelomonocyticleukemiaasatransformationfrompolycythemiavera
AT anitapandey chronicmyelomonocyticleukemiaasatransformationfrompolycythemiavera
AT borisavezbakiyev chronicmyelomonocyticleukemiaasatransformationfrompolycythemiavera
AT jenchinwang chronicmyelomonocyticleukemiaasatransformationfrompolycythemiavera
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