Medroxyprogesterone Acetate (MPA) Enhances HIV-1 Accumulation and Release in Primary Cervical Epithelial Cells by Inhibiting Lysosomal Activity

Medroxyprogesterone Acetate (MPA) Enhances HIV-1 Accumulation and Release in Primary Cervical Epithelial Cells by Inhibiting Lysosomal Activity

Medroxyprogesterone acetate (MPA) is one of the most widely used contraceptives in the world. Epidemiologic studies have uncovered a possible link between the use of MPA and an increased risk of HIV-1 transmission. However, the understanding of the mechanism is still limited. Our previous publicatio...

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Bibliographic Details
Main Authors: Xiangxu Jia, Qiujia Shao, Ahsen R. Chaudhry, Ballington L. Kinlock, Michael G. Izban, Hong-Ying Zhang, Fernando Villalta, James E. K. Hildreth, Bindong Liu
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pathogens
Subjects:
HIV-1
Medroxyprogesterone acetate
MPA
transmission
lysosome activity
Online Access:https://www.mdpi.com/2076-0817/10/9/1192

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