The central role of DNA damage and repair in CAG repeat diseases

The central role of DNA damage and repair in CAG repeat diseases

Diseases such as Huntington's disease and certain spinocerebellar ataxias are caused by the expansion of genomic cytosine-adenine-guanine (CAG) trinucleotide repeats beyond a specific threshold. These diseases are all characterised by neurological symptoms and central neurodegeneration, but our...

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Bibliographic Details
Main Authors: Thomas H. Massey, Lesley Jones
Format: Article
Language:English
Published: The Company of Biologists 2018-01-01
Series:Disease Models & Mechanisms
Subjects:
CAG repeat
DNA damage
DNA repair
Huntington's disease
Spinocerebellar ataxia
Online Access:http://dmm.biologists.org/content/11/1/dmm031930

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