Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-beta-cyclodextrin

Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-beta-cyclodextrin

<abstract language="eng">Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-ch...

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Bibliographic Details
Main Authors: Renato Grillo, Nathalie F. S. de Melo, Leonardo Fernandes Fraceto, Charles L. Brito, Gustavo H. G. Trossini, Carla M. S. Menezes, Elizabeth Igne Ferreira, Carolina Morales Moraes
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2008-01-01
Series:Química Nova
Subjects:
hydroxymethylnitrofurazone
cyclodextrin
inclusion complex
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200019

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