Protein Kinase C-theta (PKC-theta) in Natural Killer (NK) cell function and anti-tumor immunity

Protein Kinase C-theta (PKC-theta) in Natural Killer (NK) cell function and anti-tumor immunity

The protein kinase C-theta (PKCtheta), which is essential for T cell function and survival, is also required for efficient anti-tumor immune surveillance. Natural killer (NK) cells, which express PKCtheta, play a prominent role in this process, mainly by elimination of tumor cells with reduced or ab...

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Bibliographic Details
Main Authors: Alberto eAnel, Juan Ignacio Aguiló, Elena eCatalán, Johan eGaraude, Moeez Ghani Rathore, Julián ePardo, Martín eVillalba
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Immunology
Subjects:
NK cells
CTL
anti-tumor immunity
degranulation
PKC-theta
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00187/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00187/full

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