SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

Microglia represent a first-line defense in the brain. However, in pathological conditions such as Alzheimer’s disease (AD), a pro-inflammatory switch may occur, leading to loss of protective functions. Using the human microglial cell line HMC3, we showed that exposure to low concentrations of β-amy...

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Bibliographic Details
Main Authors: Grazia Ilaria Caruso, Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo, Maria Angela Sortino
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
Alzheimer’s disease
HMC3 human microglia
inflammation
microglial switch
NF-kB
Silent Information Regulator 2 homolog 1
Online Access:https://www.mdpi.com/2227-9059/9/5/466

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