Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

Bacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mecha...

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Main Authors: Hong-Bo Yang, Wen-Tao Hou, Meng-Ting Cheng, Yong-Liang Jiang, Yuxing Chen, Cong-Zhao Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02741-4
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spelling doaj-771197c9eb5a453db314d079cce6a0ba2021-05-11T09:36:08ZengNature Publishing GroupNature Communications2041-17232018-01-019111110.1038/s41467-017-02741-4Structure of a MacAB-like efflux pump from Streptococcus pneumoniaeHong-Bo Yang0Wen-Tao Hou1Meng-Ting Cheng2Yong-Liang Jiang3Yuxing Chen4Cong-Zhao Zhou5Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of ChinaBacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mechanism.https://doi.org/10.1038/s41467-017-02741-4
collection DOAJ
language English
format Article
sources DOAJ
author Hong-Bo Yang
Wen-Tao Hou
Meng-Ting Cheng
Yong-Liang Jiang
Yuxing Chen
Cong-Zhao Zhou
spellingShingle Hong-Bo Yang
Wen-Tao Hou
Meng-Ting Cheng
Yong-Liang Jiang
Yuxing Chen
Cong-Zhao Zhou
Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
Nature Communications
author_facet Hong-Bo Yang
Wen-Tao Hou
Meng-Ting Cheng
Yong-Liang Jiang
Yuxing Chen
Cong-Zhao Zhou
author_sort Hong-Bo Yang
title Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
title_short Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
title_full Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
title_fullStr Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
title_full_unstemmed Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
title_sort structure of a macab-like efflux pump from streptococcus pneumoniae
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Bacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mechanism.
url https://doi.org/10.1038/s41467-017-02741-4
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