Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

Bacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mecha...

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Bibliographic Details
Main Authors: Hong-Bo Yang, Wen-Tao Hou, Meng-Ting Cheng, Yong-Liang Jiang, Yuxing Chen, Cong-Zhao Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02741-4
Description
Summary:Bacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mechanism.
ISSN:2041-1723

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