A Mucosal Adenovirus Prime/Systemic Envelope Boost Vaccine Regimen Elicits Responses in Cervicovaginal and Alveolar Macrophages of Rhesus Macaques Associated With Delayed SIV Acquisition and B Cell Help

A Mucosal Adenovirus Prime/Systemic Envelope Boost Vaccine Regimen Elicits Responses in Cervicovaginal and Alveolar Macrophages of Rhesus Macaques Associated With Delayed SIV Acquisition and B Cell Help

Vaccine strategies targeting the mucosal portal of entry may prevent HIV acquisition and systemic infection. Macrophages in cervicovaginal compartments are one of the first cell types to encounter virus upon vaginal exposure. Their activation can lead to recruitment of additional macrophages and CD4...

Full description

Bibliographic Details
Main Authors: Ruth Hunegnaw, Sabrina Helmold Hait, Gospel Enyindah-Asonye, Mohammad Arif Rahman, Eun-Ju Ko, Christopher J. Hogge, Tanya Hoang, Marjorie Robert-Guroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
cervicovaginal macrophage
alveolar macrophage
simian immunodeficiency virus
B cell help
rhesus macaques
FcγRIII
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.571804/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.571804/full

Similar Items