EM23, a natural sesquiterpene lactone from Elephantopus mollis H.B.K., induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways

EM23, a natural sesquiterpene lactone from Elephantopus mollis H.B.K., induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways

Elephantopus mollis H.B.K. (EM) is a traditional herbal medicine with multiple pharmacological activities. However, the efficacy of EM in treating human leukemia is currently unknown. In the current study, we report that EM23, a natural sesquiterpene lactone isolated from EM, inhibits the proliferat...

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Bibliographic Details
Main Authors: Hongyu eLi, Manmei eLi, Guocai eWang, Fangyuan eShao, Wenbo eChen, Chao eXia, Sheng eWang, Yaolan eLi, Guangxiong eZhou, Zhong eLiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Apoptosis
ROS
thioredoxin
ASK1
myeloid leukemia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00077/full

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