Complex I is bypassed during high intensity exercise

During high-intensity exercise, muscles convert glucose to lactate, in a process that is energetically less efficient than respiration. Here the authors develop a computational model based on muscle proteomic data showing that bypassing mitochondrial complex I increases ATP production rates, and val...

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Bibliographic Details
Main Authors: Avlant Nilsson, Elias Björnson, Mikael Flockhart, Filip J. Larsen, Jens Nielsen
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12934-8