Versatile synthesis of the signaling peptide glorin

We present a versatile synthesis of the eukaryotic signaling peptide glorin as well as glorinamide, a synthetic analog. The ability of these compounds to activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantitative reverse transcription PCR, whereby both...

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Main Authors:	Robert Barnett, Daniel Raszkowski, Thomas Winckler, Pierre Stallforth
Format:	Article
Language:	English
Published:	Beilstein-Institut 2017-02-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	Dictyostelium glorin multicellularity Polysphondylium signaling molecules social amoebae
Online Access:	https://doi.org/10.3762/bjoc.13.27

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spelling	doaj-77077923c7ea40cda3d8be25c9628c0a2021-02-02T05:50:48ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972017-02-0113124725010.3762/bjoc.13.271860-5397-13-27Versatile synthesis of the signaling peptide glorinRobert Barnett0Daniel Raszkowski1Thomas Winckler2Pierre Stallforth3Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute – HKI, Junior Research Group Chemistry of Microbial Communication, Beutenbergstr. 11, D-07745 Jena, GermanyFaculty of Biology and Pharmacy, Institute of Pharmacy, Department of Pharmaceutical Biology, University of Jena, Semmelweisstrasse 10, D-07743 Jena, GermanyFaculty of Biology and Pharmacy, Institute of Pharmacy, Department of Pharmaceutical Biology, University of Jena, Semmelweisstrasse 10, D-07743 Jena, GermanyLeibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute – HKI, Junior Research Group Chemistry of Microbial Communication, Beutenbergstr. 11, D-07745 Jena, GermanyWe present a versatile synthesis of the eukaryotic signaling peptide glorin as well as glorinamide, a synthetic analog. The ability of these compounds to activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantitative reverse transcription PCR, whereby both compounds showed bioactivity comparable to a glorin standard. This synthetic route will be useful in conducting detailed structure–activity relationship studies as well as in the design of chemical probes to dissect glorin-mediated signaling pathways.https://doi.org/10.3762/bjoc.13.27DictyosteliumglorinmulticellularityPolysphondyliumsignaling moleculessocial amoebae
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Robert Barnett Daniel Raszkowski Thomas Winckler Pierre Stallforth
spellingShingle	Robert Barnett Daniel Raszkowski Thomas Winckler Pierre Stallforth Versatile synthesis of the signaling peptide glorin Beilstein Journal of Organic Chemistry Dictyostelium glorin multicellularity Polysphondylium signaling molecules social amoebae
author_facet	Robert Barnett Daniel Raszkowski Thomas Winckler Pierre Stallforth
author_sort	Robert Barnett
title	Versatile synthesis of the signaling peptide glorin
title_short	Versatile synthesis of the signaling peptide glorin
title_full	Versatile synthesis of the signaling peptide glorin
title_fullStr	Versatile synthesis of the signaling peptide glorin
title_full_unstemmed	Versatile synthesis of the signaling peptide glorin
title_sort	versatile synthesis of the signaling peptide glorin
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2017-02-01
description	We present a versatile synthesis of the eukaryotic signaling peptide glorin as well as glorinamide, a synthetic analog. The ability of these compounds to activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantitative reverse transcription PCR, whereby both compounds showed bioactivity comparable to a glorin standard. This synthetic route will be useful in conducting detailed structure–activity relationship studies as well as in the design of chemical probes to dissect glorin-mediated signaling pathways.
topic	Dictyostelium glorin multicellularity Polysphondylium signaling molecules social amoebae
url	https://doi.org/10.3762/bjoc.13.27
work_keys_str_mv	AT robertbarnett versatilesynthesisofthesignalingpeptideglorin AT danielraszkowski versatilesynthesisofthesignalingpeptideglorin AT thomaswinckler versatilesynthesisofthesignalingpeptideglorin AT pierrestallforth versatilesynthesisofthesignalingpeptideglorin
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Versatile synthesis of the signaling peptide glorin

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