Versatile synthesis of the signaling peptide glorin

Versatile synthesis of the signaling peptide glorin

We present a versatile synthesis of the eukaryotic signaling peptide glorin as well as glorinamide, a synthetic analog. The ability of these compounds to activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantitative reverse transcription PCR, whereby both...

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Bibliographic Details
Main Authors: Robert Barnett, Daniel Raszkowski, Thomas Winckler, Pierre Stallforth
Format: Article
Language:English
Published: Beilstein-Institut 2017-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Dictyostelium
glorin
multicellularity
Polysphondylium
signaling molecules
social amoebae
Online Access:https://doi.org/10.3762/bjoc.13.27
Description
Summary:We present a versatile synthesis of the eukaryotic signaling peptide glorin as well as glorinamide, a synthetic analog. The ability of these compounds to activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantitative reverse transcription PCR, whereby both compounds showed bioactivity comparable to a glorin standard. This synthetic route will be useful in conducting detailed structure–activity relationship studies as well as in the design of chemical probes to dissect glorin-mediated signaling pathways.
ISSN:1860-5397

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