The Mechanism of Action of Antigen Processing Independent T Cell Epitopes Designed for Immunotherapy of Autoimmune Diseases

The Mechanism of Action of Antigen Processing Independent T Cell Epitopes Designed for Immunotherapy of Autoimmune Diseases

Immunotherapy with antigen-processing independent T cell epitopes (apitopes) targeting autoreactive CD4+ T cells has translated to the clinic and been shown to modulate progression of both Graves’ disease and multiple sclerosis. The model apitope (Ac1-9[4Y]) renders antigen-specific T cells anergic...

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Bibliographic Details
Main Authors: Ella R. Shepard, Anja Wegner, Elaine V. Hill, Bronwen R. Burton, Sarah Aerts, Evelien Schurgers, Brecht Hoedemaekers, Sky T. H. Ng, Heather B. Streeter, Lotta Jansson, David C. Wraith
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
apitope
immunotherapy
immunological tolerance
interleukin-10
dendritic cell
autoimmune disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.654201/full

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