Live Dynamics of 53BP1 Foci Following Simultaneous Induction of Clustered and Dispersed DNA Damage in U2OS Cells

Live Dynamics of 53BP1 Foci Following Simultaneous Induction of Clustered and Dispersed DNA Damage in U2OS Cells

Cells react differently to clustered and dispersed DNA double strand breaks (DSB). Little is known about the initial reaction to simultaneous induction of DSBs with different complexities. Here, we used live cell microscopy to analyse the behaviour of 53BP1-GFP (green fluorescence protein) foci form...

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Bibliographic Details
Main Authors: Alice Sollazzo, Beata Brzozowska, Lei Cheng, Lovisa Lundholm, Harry Scherthan, Andrzej Wojcik
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
clustered DSB
alpha particles
X-rays
53BP1 foci
live cell imaging
Online Access:http://www.mdpi.com/1422-0067/19/2/519

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