A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo.

Evidence suggests that stimulating apoptosis in malignant cells without inflicting collateral damage to the host's normal tissues is a promising cancer therapy. Chemo- and radiation therapies that, especially if combined, induce apoptosis in tumor cells have been used for treating cancer patien...

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Bibliographic Details
Main Authors: Dmitri Rozanov, Paul Spellman, Alexei Savinov, Alex Y Strongin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4388654?pdf=render