Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

A physiologically based pharmacokinetic (PBPK) model of selegiline (SEL), and its metabolites, was developed in silico to evaluate the disposition differences between healthy and special populations. SEL is metabolized to methamphetamine (MAP) and desmethyl selegiline (DMS) by several CYP enzymes. C...

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Bibliographic Details
Main Authors: Santosh Kumar Puttrevu, Sumit Arora, Sebastian Polak, Nikunj Kumar Patel
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
selegiline
transdermal
multi-phase multi-layer mechanistic dermal absorption (mpml-mechderma) model
parent and metabolite PBPK model
special populations
Online Access:https://www.mdpi.com/1999-4923/12/10/942

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