Computational Studies for Structure-Based Drug Designing Against Transmembrane Receptors: pLGICs and Class A GPCRs

Computational Studies for Structure-Based Drug Designing Against Transmembrane Receptors: pLGICs and Class A GPCRs

Biological cell is the fundamental building block of every living system. The plasma membrane, a phospholipid bilayer consisting of two asymmetric leaflets, defines its existence by separating the interior from the exterior. This low dielectric barrier selectively prevents the passage of hydrophilic...

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Bibliographic Details
Main Authors: Pavan V. Payghan, Indrani Bera, Dhananjay Bhattacharyya, Nanda Ghoshal
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physics
Subjects:
pLGIC
GPCRs
GABA A receptor
structure based drug design
MD simulations
CNS drug discovery
Online Access:https://www.frontiersin.org/article/10.3389/fphy.2018.00052/full

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