Preserved cardiac function despite marked impairment of cAMP generation.

Preserved cardiac function despite marked impairment of cAMP generation.

So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+) using agents that do not affect cAMP. Although lef...

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Bibliographic Details
Main Authors: Mei Hua Gao, Ngai Chin Lai, Tong Tang, Tracy Guo, Ruoying Tang, Byeong Jo Chun, Hong Wang, Nancy N Dalton, Jorge Suarez, Wolfgang H Dillmann, H Kirk Hammond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797917?pdf=render

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