Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

AIMS: In collateral development (i.e. arteriogenesis), mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR)1 and PAR2 are G-protein-coupled receptors that are both expre...

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Main Authors: Lisa G van den Hengel, Alwine A Hellingman, Anne Yael Nossent, Annemarie M van Oeveren-Rietdijk, Margreet R de Vries, C Arnold Spek, Anton Jan van Zonneveld, Pieter H Reitsma, Jaap F Hamming, Hetty C de Boer, Henri H Versteeg, Paul H A Quax
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3630144?pdf=render

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