Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation

Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation

The proliferation of intestinal stem cells (ISCs) and differentiation of enteroblasts to form mature enteroendocrine cells and enterocytes in the Drosophila intestinal epithelium must be tightly regulated to maintain homeostasis. We show that genetic modulation of CyclinD/Cdk4 activity or mTOR-depen...

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Bibliographic Details
Main Authors: Mojca Adlesic, Christian Frei, Ian J. Frew
Format: Article
Language:English
Published: The Company of Biologists 2016-03-01
Series:Biology Open
Subjects:
Enterocyte
Intestinal stem cell
Homeostasis
Cdk4
Niche
Online Access:http://bio.biologists.org/content/5/3/237

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