Huntington's Disease: An Immune Perspective

Huntington's Disease: An Immune Perspective

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brai...

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Main Authors: Annapurna Nayak, Rafia Ansar, Sunil K. Verma, Domenico Marco Bonifati, Uday Kishore
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2011/563784
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spelling doaj-76cd27494ba541549341a20f9644abd22020-11-25T00:08:13ZengHindawi LimitedNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/563784563784Huntington's Disease: An Immune PerspectiveAnnapurna Nayak0Rafia Ansar1Sunil K. Verma2Domenico Marco Bonifati3Uday Kishore4Centre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UKCentre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UKCentre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, IndiaUnit of Neurology, Department of Neurological Disorders, Santa Chiara Hospital, Largo Medaglie d'oro 1, 38100 Trento, ItalyCentre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UKHuntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.http://dx.doi.org/10.1155/2011/563784
collection DOAJ
language English
format Article
sources DOAJ
author Annapurna Nayak
Rafia Ansar
Sunil K. Verma
Domenico Marco Bonifati
Uday Kishore
spellingShingle Annapurna Nayak
Rafia Ansar
Sunil K. Verma
Domenico Marco Bonifati
Uday Kishore
Huntington's Disease: An Immune Perspective
Neurology Research International
author_facet Annapurna Nayak
Rafia Ansar
Sunil K. Verma
Domenico Marco Bonifati
Uday Kishore
author_sort Annapurna Nayak
title Huntington's Disease: An Immune Perspective
title_short Huntington's Disease: An Immune Perspective
title_full Huntington's Disease: An Immune Perspective
title_fullStr Huntington's Disease: An Immune Perspective
title_full_unstemmed Huntington's Disease: An Immune Perspective
title_sort huntington's disease: an immune perspective
publisher Hindawi Limited
series Neurology Research International
issn 2090-1852
2090-1860
publishDate 2011-01-01
description Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.
url http://dx.doi.org/10.1155/2011/563784
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AT rafiaansar huntingtonsdiseaseanimmuneperspective
AT sunilkverma huntingtonsdiseaseanimmuneperspective
AT domenicomarcobonifati huntingtonsdiseaseanimmuneperspective
AT udaykishore huntingtonsdiseaseanimmuneperspective
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