Increased β-Cell Replication and β-Cell Mass Regeneration in Syngeneically Transplanted Rat Islets Overexpressing Insulin-Like Growth Factor II

Increased β-Cell Replication and β-Cell Mass Regeneration in Syngeneically Transplanted Rat Islets Overexpressing Insulin-Like Growth Factor II

Insulin-like growth factor II (IGF2) is a growth-promoting peptide that increases β-cell proliferation and survival. The aim of the study was to determine the effect of IGF2 overexpression on β-cell mass in transplanted islets. Islets infected with adenovirus encoding for IGF2 (Ad-IGF2 group), for l...

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Bibliographic Details
Main Authors: Elisabet Estil·les, Noèlia Téllez, Jessica Escoriza, Eduard Montanya
Format: Article
Language:English
Published: SAGE Publishing 2012-10-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X638955

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