Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors

Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors

The development of CRISPR/Cas9-mediated base editors (BEs) provided a versatile tool for precise genome editing. The recently developed xCas9-derived base editors (xBEs) that recognize the NG PAM substantially expand the targeting scope in the genome, while their editing efficiency needs to be impro...

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Bibliographic Details
Main Authors: Xinyi Liu, Guanglei Li, Xueliang Zhou, Yunbo Qiao, Ruixuan Wang, Shaohui Tang, Jianqiao Liu, Lisheng Wang, Xingxu Huang
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253119301891

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