Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated o...

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Main Authors:	Caroline Coombs, Antonios Georgantzoglou, Hazel A. Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M. Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13107-3

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spelling	doaj-76af9888082741848d9ffe0c719d51182021-05-11T12:18:25ZengNature Publishing GroupNature Communications2041-17232019-11-0110111710.1038/s41467-019-13107-3Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafishCaroline Coombs0Antonios Georgantzoglou1Hazel A. Walker2Julian Patt3Nicole Merten4Hugo Poplimont5Elisabeth M. Busch-Nentwich6Sarah Williams7Christina Kotsi8Evi Kostenis9Milka Sarris10Department of Physiology, Development and Neuroscience, University of CambridgeDepartment of Physiology, Development and Neuroscience, University of CambridgeDepartment of Physiology, Development and Neuroscience, University of CambridgeInstitute for Pharmaceutical Biology, University of BonnInstitute for Pharmaceutical Biology, University of BonnDepartment of Physiology, Development and Neuroscience, University of CambridgeWellcome Sanger InstituteDepartment of Physiology, Development and Neuroscience, University of CambridgeDepartment of Physiology, Development and Neuroscience, University of CambridgeInstitute for Pharmaceutical Biology, University of BonnDepartment of Physiology, Development and Neuroscience, University of CambridgeInflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated on activated neutrophils to control their clustering and dispersal, respectively.https://doi.org/10.1038/s41467-019-13107-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Caroline Coombs Antonios Georgantzoglou Hazel A. Walker Julian Patt Nicole Merten Hugo Poplimont Elisabeth M. Busch-Nentwich Sarah Williams Christina Kotsi Evi Kostenis Milka Sarris
spellingShingle	Caroline Coombs Antonios Georgantzoglou Hazel A. Walker Julian Patt Nicole Merten Hugo Poplimont Elisabeth M. Busch-Nentwich Sarah Williams Christina Kotsi Evi Kostenis Milka Sarris Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish Nature Communications
author_facet	Caroline Coombs Antonios Georgantzoglou Hazel A. Walker Julian Patt Nicole Merten Hugo Poplimont Elisabeth M. Busch-Nentwich Sarah Williams Christina Kotsi Evi Kostenis Milka Sarris
author_sort	Caroline Coombs
title	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_short	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_full	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_fullStr	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_full_unstemmed	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_sort	chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-11-01
description	Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated on activated neutrophils to control their clustering and dispersal, respectively.
url	https://doi.org/10.1038/s41467-019-13107-3
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Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

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