Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53.

Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53.

Pancreatic cancer, despite being the most dreadful among gastrointestinal cancers, is poorly diagnosed, and further, the situation has been aggravated owing to acquired drug resistance against the single known drug therapy. While previous studies have highlighted the growth inhibitory effects of old...

Full description

Bibliographic Details
Main Authors:	Vikas Yadav, Sarwat Sultana, Jyoti Yadav, Neeru Saini
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3485023?pdf=render

Similar Items

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest
by: Clarke Alan R, et al.
Published: (2002-11-01)

Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol
by: Huang Zhiwei, et al.
Published: (2015-12-01)

The Effects of Epstein-Barr Virus DNase on Cell Cycle Regulatory Proteins p53 and p27
by: Ya-Ping Tsai, et al.
Published: (2002)

Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21Cip1 and p27Kip1
by: Hyang Jee, et al.
Published: (2013-01-01)

The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest
by: Katelyn M. Atkins, et al.
Published: (2014-09-01)

LincRNA-p21 leads to G1 arrest by p53 pathway in esophageal squamous cell carcinoma
by: Zhang Y, et al.
Published: (2019-07-01)

Deficiency of G1 regulators P53, P21<sup>Cip1 </sup>and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest
by: Harrison David J, et al.
Published: (2007-11-01)

Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest
by: Celine J. Granier, et al.
Published: (2014-08-01)

Oridonin induces Mdm2‐p60 to promote p53‐mediated apoptosis and cell cycle arrest in neuroblastoma
by: Han‐Qing Zhu, et al.
Published: (2019-09-01)

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo
by: Karimian H, et al.
Published: (2017-02-01)

Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics.
by: Hiroyuki Hamada, et al.
Published: (2009-01-01)

Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas.
by: Carlos S Moreno, et al.
Published: (2007-05-01)

Induction of apoptosis or cell cycle arrest by two human wildtype variants of the p53 protein
by: Azoulay, Eric.
Published: (1999)

The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study
by: Recep Bedir, et al.
Published: (2016-04-01)

DNA Replication Arrest and P53-Dependent and P53-Independent Cell Death Pathways in Xeroderma Pigmentosum Variant Cells
by: James E. Cleaver, et al.
Published: (2001-01-01)

Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21waf1 pathway in glioma cell
by: Kano, Hideyuki
Published: (2011)

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway
by: Haibiao Xie, et al.
Published: (2021-01-01)

Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27
by: Karimian H, et al.
Published: (2014-09-01)

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1
by: Yuanyuan Zhou, et al.
Published: (2016-12-01)

Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation.
by: Natalia Bailon-Moscoso, et al.
Published: (2015-01-01)

A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest
by: Michael Tsabar, et al.
Published: (2020-08-01)

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis.
by: Gang Li, et al.
Published: (2017-01-01)

Functional dissecting of a critical molecular determinant in p53-induced cell cycle arrest and apoptosis
by: Tsai,Shih-Yan, et al.
Published: (2004)

Correction: Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation.
by: Natalia Bailon-Moscoso, et al.
Published: (2017-01-01)

The effect of p53 and M3-p53 overexpression on cell cycle, metabolism, and myogenesis
by: Lulus Putri Aninda, et al.
Published: (2019)

Effect and mechanism of high glucose on apoptosis and cell cycle arrest of islet β cells via p27 pathway
by: Yu-Xi Qiao, et al.
Published: (2021-03-01)

The Antiproliferative Activity of Oxypeucedanin via Induction of G<sub>2</sub>/M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells
by: So Hyun Park, et al.
Published: (2020-01-01)

Identification of the p53 regulation site on p27 promoter
by: Po-Han Lin, et al.
Published: (2010)

Influences of Resveratrol on the Proliferation of Cholangiocarcinoma Cells and Expression of p21 and p27 Proteins
by: Yong Liu, et al.
Published: (2013-12-01)

Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells
by: Zhu Hai-Bin, et al.
Published: (2013-01-01)

CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.
by: Shu Zhang, et al.
Published: (2015-01-01)

Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21<sup>WAF1/CIP1</sup> and p27<sup>KIP1</sup> in Cancer Cells
by: Umamaheswari Natarajan, et al.
Published: (2019-01-01)

Loss of p53 Induces Tumorigenesis in p21-Deficient Mesenchymal Stem Cells
by: Rene Rodriguez, et al.
Published: (2009-04-01)

Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
by: Hong, Hyenｊong
Published: (2012)

Risk of wild fungi treatment failure: Phallus impudicus-induced telomere damage triggers p21/p53 and p16-dependent cell cycle arrest and may contribute to male fertility reduction in vitro
by: Przemyslaw Solek, et al.
Published: (2021-02-01)

EFNB2 facilitates cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via the p53/p21 pathway and EMT
by: Feng Zhu, et al.
Published: (2020-05-01)

Expression of the cell cycle regulation proteins p53 and p21WAF1 in different types of non-dysplastic leukoplakias
by: Fernanda Visioli, et al.
Published: (2012-06-01)

Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest.
by: Julie Lafontaine, et al.
Published: (2012-01-01)

Radiation-induced Phosphorylation of Chk1 at S345 is Associated with p53-dependent Cell Cycle Arrest Pathways
by: Hui Tian, et al.
Published: (2002-01-01)

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
by: Chii Shyang Fong, et al.
Published: (2016-07-01)

Cannot write session to /tmp/vufind_sessions/sess_2kv5blk69597705vt8020cjj5e