Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases

<p>Abstract</p> <p>Background</p> <p>Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of the infectious disease i...

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Main Authors: Vo Thi, Godard Patrice, de Saint-Hubert Marie, Morrhaye Gabriel, Swine Christian, Geenen Vincent, Martens Henri J, Debacq-Chainiaux Florence, Toussaint Olivier
Format: Article
Language:English
Published: BMC 2010-08-01
Series:Immunity & Ageing
Online Access:http://www.immunityageing.com/content/7/1/9
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spelling doaj-76a55c30a90147d18ad29838e86ab1f12020-11-24T23:58:14ZengBMCImmunity & Ageing1742-49332010-08-0171910.1186/1742-4933-7-9Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseasesVo ThiGodard Patricede Saint-Hubert MarieMorrhaye GabrielSwine ChristianGeenen VincentMartens Henri JDebacq-Chainiaux FlorenceToussaint Olivier<p>Abstract</p> <p>Background</p> <p>Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of the infectious disease is poorly understood.</p> <p>Results</p> <p>Herein the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of 28 healthy aged probands and 39 aged patients in acute phase of infectious disease (day 2-4 after hospitalization) or in convalescence phase (day 7-10). This study provides a list of 24 differentially abundant transcript species in the acute phase versus healthy aged. For instance, transcripts associated with inflammatory and anti-inflammatory reactions (TNFRSF1A, IL1R1, IL1R2, IL10RB) and with oxidative stress (HMOX1, GPX1, SOD2, PRDX6) were more abundant while those associated with T-cell functions (CD28, CD69, LCK) were less abundant in acute phase. The abundance of seven of these transcripts (CD28, CD69, LCK, CTSD, HMOX1, TNFRSF1A and PRDX6) was already known to be altered in healthy aged probands compared to healthy young ones and was further affected in aged patients in acute phase, compromising an efficient response.</p> <p>Conclusion</p> <p>This work provides insights of the state of acute phase response to infections in elderly patients and could explain further the lack of appropriate response in the elderly compared to younger persons.</p> http://www.immunityageing.com/content/7/1/9
collection DOAJ
language English
format Article
sources DOAJ
author Vo Thi
Godard Patrice
de Saint-Hubert Marie
Morrhaye Gabriel
Swine Christian
Geenen Vincent
Martens Henri J
Debacq-Chainiaux Florence
Toussaint Olivier
spellingShingle Vo Thi
Godard Patrice
de Saint-Hubert Marie
Morrhaye Gabriel
Swine Christian
Geenen Vincent
Martens Henri J
Debacq-Chainiaux Florence
Toussaint Olivier
Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
Immunity & Ageing
author_facet Vo Thi
Godard Patrice
de Saint-Hubert Marie
Morrhaye Gabriel
Swine Christian
Geenen Vincent
Martens Henri J
Debacq-Chainiaux Florence
Toussaint Olivier
author_sort Vo Thi
title Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
title_short Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
title_full Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
title_fullStr Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
title_full_unstemmed Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
title_sort transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
publisher BMC
series Immunity & Ageing
issn 1742-4933
publishDate 2010-08-01
description <p>Abstract</p> <p>Background</p> <p>Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of the infectious disease is poorly understood.</p> <p>Results</p> <p>Herein the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of 28 healthy aged probands and 39 aged patients in acute phase of infectious disease (day 2-4 after hospitalization) or in convalescence phase (day 7-10). This study provides a list of 24 differentially abundant transcript species in the acute phase versus healthy aged. For instance, transcripts associated with inflammatory and anti-inflammatory reactions (TNFRSF1A, IL1R1, IL1R2, IL10RB) and with oxidative stress (HMOX1, GPX1, SOD2, PRDX6) were more abundant while those associated with T-cell functions (CD28, CD69, LCK) were less abundant in acute phase. The abundance of seven of these transcripts (CD28, CD69, LCK, CTSD, HMOX1, TNFRSF1A and PRDX6) was already known to be altered in healthy aged probands compared to healthy young ones and was further affected in aged patients in acute phase, compromising an efficient response.</p> <p>Conclusion</p> <p>This work provides insights of the state of acute phase response to infections in elderly patients and could explain further the lack of appropriate response in the elderly compared to younger persons.</p>
url http://www.immunityageing.com/content/7/1/9
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