Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

Inherited retinal diseases (IRDs) are clinically and genetically heterogenous diseases affecting the neural retina and retinal pigment epithelium resulting in irreversible blindness. Owing to advantages like ease of access for treatment, one eye being a perfect natural control for the other, and imm...

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Main Authors: Vijay Bhaskar Reddy Konala, Swapna Nandakumar, Rajani Battu, Rajarshi Pal
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120300611
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spelling doaj-769e69675be54b87a03c3a667cc754542020-11-25T03:26:39ZengElsevierStem Cell Research1873-50612020-05-0145Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutationsVijay Bhaskar Reddy Konala0Swapna Nandakumar1Rajani Battu2Rajarshi Pal3Eyestem Research Private Limited, C-CAMP, GKVK Post, Bangalore 560065, Karnataka, IndiaEyestem Research Private Limited, C-CAMP, GKVK Post, Bangalore 560065, Karnataka, IndiaCentre for Eye Genetics and Research, Cytecare Hospital, Bangalore 560064, Karnataka, IndiaEyestem Research Private Limited, C-CAMP, GKVK Post, Bangalore 560065, Karnataka, India; Corresponding author.Inherited retinal diseases (IRDs) are clinically and genetically heterogenous diseases affecting the neural retina and retinal pigment epithelium resulting in irreversible blindness. Owing to advantages like ease of access for treatment, one eye being a perfect natural control for the other, and immune privileged environment, research exploring treatment for these retinal diseases has advanced remarkably. We describe the generation of induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMC) of three patients with IRDs. These well-characterized iPSC lines provide an ideal platform to investigate normal and pathological retinogenesis for drug screening and personalized cell therapy.http://www.sciencedirect.com/science/article/pii/S1873506120300611
collection DOAJ
language English
format Article
sources DOAJ
author Vijay Bhaskar Reddy Konala
Swapna Nandakumar
Rajani Battu
Rajarshi Pal
spellingShingle Vijay Bhaskar Reddy Konala
Swapna Nandakumar
Rajani Battu
Rajarshi Pal
Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations
Stem Cell Research
author_facet Vijay Bhaskar Reddy Konala
Swapna Nandakumar
Rajani Battu
Rajarshi Pal
author_sort Vijay Bhaskar Reddy Konala
title Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations
title_short Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations
title_full Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations
title_fullStr Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations
title_full_unstemmed Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations
title_sort derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (pbmc) of indian patients suffering from inherited retinal diseases carrying different mutations
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2020-05-01
description Inherited retinal diseases (IRDs) are clinically and genetically heterogenous diseases affecting the neural retina and retinal pigment epithelium resulting in irreversible blindness. Owing to advantages like ease of access for treatment, one eye being a perfect natural control for the other, and immune privileged environment, research exploring treatment for these retinal diseases has advanced remarkably. We describe the generation of induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMC) of three patients with IRDs. These well-characterized iPSC lines provide an ideal platform to investigate normal and pathological retinogenesis for drug screening and personalized cell therapy.
url http://www.sciencedirect.com/science/article/pii/S1873506120300611
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AT swapnanandakumar derivationofthreeinducedpluripotentstemcelllinesunderfeederfreecultureconditionsfromperipheralbloodmononuclearcellspbmcofindianpatientssufferingfrominheritedretinaldiseasescarryingdifferentmutations
AT rajanibattu derivationofthreeinducedpluripotentstemcelllinesunderfeederfreecultureconditionsfromperipheralbloodmononuclearcellspbmcofindianpatientssufferingfrominheritedretinaldiseasescarryingdifferentmutations
AT rajarshipal derivationofthreeinducedpluripotentstemcelllinesunderfeederfreecultureconditionsfromperipheralbloodmononuclearcellspbmcofindianpatientssufferingfrominheritedretinaldiseasescarryingdifferentmutations
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