Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

Extracellular matrix (ECM) remodelling is thought to have effects on muscle stem cells that support muscle homeostasis. Here the authors show ECM remodeling controls satellite cell self-renewal through deposition of laminin-α1 into the satellite cell niche.

Bibliographic Details
Main Authors: Shantisree Sandeepani Rayagiri, Daniele Ranaldi, Alexander Raven, Nur Izzah Farhana Mohamad Azhar, Olivier Lefebvre, Peter S Zammit, Anne-Gaëlle Borycki
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03425-3
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spelling doaj-769c8e79a91d443abc08b2d2575d38d82021-05-11T09:33:24ZengNature Publishing GroupNature Communications2041-17232018-03-019111210.1038/s41467-018-03425-3Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewalShantisree Sandeepani Rayagiri0Daniele Ranaldi1Alexander Raven2Nur Izzah Farhana Mohamad Azhar3Olivier Lefebvre4Peter S Zammit5Anne-Gaëlle Borycki6Department of Biomedical Science, University of Sheffield, Firth CourtDepartment of Biomedical Science, University of Sheffield, Firth CourtDepartment of Biomedical Science, University of Sheffield, Firth CourtDepartment of Biomedical Science, University of Sheffield, Firth CourtInserm U1109 MN3TRandall Centre for Cell and Molecular Biophysics, Faculty of Life Sciences & Medicine King’s College London, New Hunt’s HouseDepartment of Biomedical Science, University of Sheffield, Firth CourtExtracellular matrix (ECM) remodelling is thought to have effects on muscle stem cells that support muscle homeostasis. Here the authors show ECM remodeling controls satellite cell self-renewal through deposition of laminin-α1 into the satellite cell niche.https://doi.org/10.1038/s41467-018-03425-3
collection DOAJ
language English
format Article
sources DOAJ
author Shantisree Sandeepani Rayagiri
Daniele Ranaldi
Alexander Raven
Nur Izzah Farhana Mohamad Azhar
Olivier Lefebvre
Peter S Zammit
Anne-Gaëlle Borycki
spellingShingle Shantisree Sandeepani Rayagiri
Daniele Ranaldi
Alexander Raven
Nur Izzah Farhana Mohamad Azhar
Olivier Lefebvre
Peter S Zammit
Anne-Gaëlle Borycki
Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
Nature Communications
author_facet Shantisree Sandeepani Rayagiri
Daniele Ranaldi
Alexander Raven
Nur Izzah Farhana Mohamad Azhar
Olivier Lefebvre
Peter S Zammit
Anne-Gaëlle Borycki
author_sort Shantisree Sandeepani Rayagiri
title Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
title_short Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
title_full Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
title_fullStr Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
title_full_unstemmed Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
title_sort basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-03-01
description Extracellular matrix (ECM) remodelling is thought to have effects on muscle stem cells that support muscle homeostasis. Here the authors show ECM remodeling controls satellite cell self-renewal through deposition of laminin-α1 into the satellite cell niche.
url https://doi.org/10.1038/s41467-018-03425-3
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AT peterszammit basallaminaremodelingattheskeletalmusclestemcellnichemediatesstemcellselfrenewal
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