Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
The adaptor protein zyxin is known for its mechanosensing function in the maintenance of actin network. Here the authors show that zyxin is key to blood homeostasis and thrombosis by controlling the endothelial release of von Willebrand factor and the formation of actin scaffolds on exocytic granule...
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Bibliographic Details
| Main Authors: |
Xiaofan Han,
Pin Li,
Zhenghao Yang,
Xiaoshuai Huang,
Guoqin Wei,
Yujie Sun,
Xuya Kang,
Xueting Hu,
Qiuping Deng,
Liangyi Chen,
Aibin He,
Yingqing Huo,
Dong Li,
Eric Betzig,
Jincai Luo |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14639
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