Feedback regulation of crystal growth by buffering monomer concentration

Feedback regulation of crystal growth by buffering monomer concentration

Gaining control over crystallization processes is challenging. Herein, the authors describe a protocol for the controlled growth of DNA nanotubes by feedback regulation: the coupling of a reversible bimolecular monomer buffering reaction delivers the optimal monomer concentration and leads to reliab...

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Main Authors: Samuel W. Schaffter, Dominic Scalise, Terence M. Murphy, Anusha Patel, Rebecca Schulman
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19882-8
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spelling doaj-7694235319dd4daeba447ac6fd30051b2021-05-11T08:44:52ZengNature Publishing GroupNature Communications2041-17232020-11-0111111210.1038/s41467-020-19882-8Feedback regulation of crystal growth by buffering monomer concentrationSamuel W. Schaffter0Dominic Scalise1Terence M. Murphy2Anusha Patel3Rebecca Schulman4Chemical & Biomolecular Engineering, Johns Hopkins UniversityChemical & Biomolecular Engineering, Johns Hopkins UniversityOur Lady of Lourdes High SchoolChemical & Biomolecular Engineering, Johns Hopkins UniversityChemical & Biomolecular Engineering, Johns Hopkins UniversityGaining control over crystallization processes is challenging. Herein, the authors describe a protocol for the controlled growth of DNA nanotubes by feedback regulation: the coupling of a reversible bimolecular monomer buffering reaction delivers the optimal monomer concentration and leads to reliable crystal growth in a simple manner.https://doi.org/10.1038/s41467-020-19882-8
collection DOAJ
language English
format Article
sources DOAJ
author Samuel W. Schaffter
Dominic Scalise
Terence M. Murphy
Anusha Patel
Rebecca Schulman
spellingShingle Samuel W. Schaffter
Dominic Scalise
Terence M. Murphy
Anusha Patel
Rebecca Schulman
Feedback regulation of crystal growth by buffering monomer concentration
Nature Communications
author_facet Samuel W. Schaffter
Dominic Scalise
Terence M. Murphy
Anusha Patel
Rebecca Schulman
author_sort Samuel W. Schaffter
title Feedback regulation of crystal growth by buffering monomer concentration
title_short Feedback regulation of crystal growth by buffering monomer concentration
title_full Feedback regulation of crystal growth by buffering monomer concentration
title_fullStr Feedback regulation of crystal growth by buffering monomer concentration
title_full_unstemmed Feedback regulation of crystal growth by buffering monomer concentration
title_sort feedback regulation of crystal growth by buffering monomer concentration
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Gaining control over crystallization processes is challenging. Herein, the authors describe a protocol for the controlled growth of DNA nanotubes by feedback regulation: the coupling of a reversible bimolecular monomer buffering reaction delivers the optimal monomer concentration and leads to reliable crystal growth in a simple manner.
url https://doi.org/10.1038/s41467-020-19882-8
work_keys_str_mv AT samuelwschaffter feedbackregulationofcrystalgrowthbybufferingmonomerconcentration
AT dominicscalise feedbackregulationofcrystalgrowthbybufferingmonomerconcentration
AT terencemmurphy feedbackregulationofcrystalgrowthbybufferingmonomerconcentration
AT anushapatel feedbackregulationofcrystalgrowthbybufferingmonomerconcentration
AT rebeccaschulman feedbackregulationofcrystalgrowthbybufferingmonomerconcentration
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