A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

To obtain a high-efficiency drug and gene co-delivery system to HNE-1 tumor therapy, a polymeric prodrug (PAAs-MTX) with chemotherapeutic sensibilization was synthesized consisting of a GSH-response hyperbranched poly(amido amine) (PAAs) and an antitumor drug of methotrexate (MTX). Then, the targeti...

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Bibliographic Details
Main Authors: Tao Liu, Xidong Wu, Shaohua Chen, Peina Wu, Hong Han, Hongbin Zhang, Junzheng Li, Guanxue Li, Siyi Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
chemotherapeutic sensibilization
polymeric prodrug
drug and gene co-delivery
nasopharyngeal carcinoma
Online Access:http://dx.doi.org/10.1080/10717544.2019.1698674

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