Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids

Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids

Abstract Background Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exosomes have shown anti-senescence effects in various diseases. We applied...

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Bibliographic Details
Main Authors: Wenyi Chen, Jiaqi Zhu, Feiyan Lin, Yanping Xu, Bing Feng, Xudong Feng, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li, Hongcui Cao
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
Primary sclerosing cholangitis
Senescence
Cholangiocytes
Organoids
Online Access:https://doi.org/10.1186/s13287-021-02271-3

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