Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives

A series of novel 6-pyrazolinylcoumarins has been synthesized via multi-step protocol. The synthetic procedure was based on the acetylation of hydroxycoumarins; Fries rearrangement and Claisen–Schmidt condensation; the target 6-[5-aryl-4,5-dihydropyrazol-3-yl]-5-hydroxy-7-methylcoumarins (33–49) wer...

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Bibliographic Details
Main Authors: Yana Garazd, Myroslav Garazd, Roman Lesyk
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Saudi Pharmaceutical Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016416300330