New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistance to Current Strategies for Targeting MDSCs

New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistance to Current Strategies for Targeting MDSCs

Cancer cells “hijack” host immune cells to promote growth, survival, and metastasis. The immune microenvironment of high-grade gliomas (HGG) is a complex and heterogeneous system, consisting of diverse cell types such as microglia, bone marrow-derived macrophages (BMDMs), myeloid-derived suppressor...

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Bibliographic Details
Main Authors: Senthilnath Lakshmanachetty, Joselyn Cruz-Cruz, Eric Hoffmeyer, Allison P. Cole, Siddhartha S. Mitra
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
MDSCs
glioma
glioblastoma
high-grade glioma
brain tumors
metabolic reprogramming
Online Access:https://www.mdpi.com/2073-4409/10/4/893

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