Intraventricular glioneuronal tumor with disseminated lesions at diagnosis - a case report -

• Main Authors: Yano Hirohito, Nakayama Noriyuki, Hirose Yoshinobu, Ohe Naoyuki, Shinoda Jun, Yoshimura Shin-ichi, Iwama Toru
• Format: Article
• Language: English
• Published: BMC 2011-12-01
• Series: Diagnostic Pathology
• Subjects: dissemination; glioneuronal tumor; immunohistochemistry; intensity-modulated radiation therapy; temozolomide
• Online Access: http://www.diagnosticpathology.org/content/6/1/119

<p>Abstract</p> <p>A 55-year-old man presented with a large tumor in his lateral ventricles. Magnetic resonance imaging revealed disseminated lesions in the third and fourth ventricles at the time of diagnosis. The patient underwent a partial removal of the tumor in the lateral ventricles. Histologically, the surgical specimens showed glioneuronal differentiation with ganglion or ganglioid cells, Rosenthal fibers, oligodendroglia-like honeycomb appearances, a spongy pattern, perivascular pseudorosettes, and many hyalinized blood vessels. Papillary structure was not observed. The neuronal component showed a moderately high labeling index of Ki-67/MIB-1. We diagnosed this tumor as atypical intraventricular glioneuronal tumor. The disseminated lesions disappeared after chemoradiation therapy with temozolomide, and the residual tumors in the lateral ventricles remained stable for 3 years after the surgery. We discuss the pathological diagnosis, therapy and clinical course with review of the literatures.</p>