Expression of yeast NDI1 rescues a Drosophila complex I assembly defect.

Expression of yeast NDI1 rescues a Drosophila complex I assembly defect.

Defects in mitochondrial electron transport chain (ETC) function have been implicated in a number of neurodegenerative disorders, cancer, and aging. Mitochondrial complex I (NADH dehydrogenase) is the largest and most complicated enzyme of the ETC with 45 subunits originating from two separate genom...

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Bibliographic Details
Main Authors: Jaehyoung Cho, Jae H Hur, Jacqueline Graniel, Seymour Benzer, David W Walker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511326?pdf=render

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