A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation

A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation

A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditio...

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Bibliographic Details
Main Authors: Deyu Hu, Qianzhu Li, Linhong Jin, Song Yang, Huiping Zhang, Baoan Song, Guiping Ouyang
Format: Article
Language:English
Published: MDPI AG 2005-10-01
Series:Molecules
Subjects:
2-Cyanoacrylate
aromatic amine
aminopyridine
microwave irradiation.
Online Access:http://www.mdpi.com/1420-3049/10/10/1351/
Description
Summary:A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.
ISSN:1420-3049

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